Clinics (Sao Paulo). 2017 February; 72(2): 125-129.
Copyright © 2017 CLINICS
Faculdade de Medicina da Universidade de São Paulo, Departamento de Emergências Clínicas, São Paulo/SP, Brazil
*Corresponding author. E-mail:
received July 31, 2016; revised September 19, 2016; accepted October 10, 2016.
We aimed to assess the effects of diazoxide on the mortality, pancreatic injury, and inflammatory response in an experimental model of acute pancreatitis.
Male Wistar rats (200–400 g) were divided randomly into two groups. Fifteen minutes before surgery, animals received physiological (0.9%) saline (3 mL/kg) (control group) or 45 mg/kg diazoxide (treatment group)
Mortality at 72 h was 33% in the control group and 60% in the treatment group (
Treatment with diazoxide can reduce necrosis of acinar cells in an experimental model of acute pancreatitis, but does not affect the inflammatory response or mortality after 72 h.
Keywords: Pancreatitis, Diazoxide, Rats
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