CLINICS

Clinics (Sao Paulo). 2017 February; 72(2): 106-110.
doi:10.6061/clinics/2017(02)07

Copyright © 2017 CLINICS

Non-HDL cholesterol is a good predictor of the risk of increased arterial stiffness in postmenopausal women in an urban Brazilian population

Rafael de Oliveira Alvim I * , Carlos Alberto Mourao III , Géssica Lopes Magalhães II , Camila Maciel de Oliveira II , José Eduardo Krieger II , José Geraldo Mill I , Alexandre Costa Pereira II

Universidade Federal do Espírito Santo, Departamento de Saúde Pública, Vitória/ES, Brazil

Faculdade de Medicina da Universidade de São Paulo, Instituto do Coração (INCOR), Laboratório de Genética e Cardiologia Molecular, São Paulo/SP, Brazil

Universidade Federal de Juiz de Fora, Departamento Fisiologia, Juiz de Fora/MG, Brazil

*Corresponding author. E-mail: alvimfaefid@ig.com.br

received August 9, 2016; revised October 7, 2016; accepted November 24, 2016.

Abstract

OBJECTIVES:

Increased arterial stiffness is an important determinant of the risk of cardiovascular disease. Lipid profile impairment, especially hypercholesterolemia, is associated with stiffer blood vessels. Thus, the aim of this study was to determine which of the five circulating lipid components (high-density lipoprotein cholesterol (HDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), low-density lipoprotein cholesterol (LDL), total cholesterol (TC) and triglycerides) is the best predictor of increased arterial stiffness in an urban Brazilian population.

METHODS:

A random sample of 1,662 individuals from the general population of Vitoria, Brazil (25-64 years), was selected, and lipid components were measured using standard methods. Pulse wave velocity was measured using a non-invasive automatic device, and increased arterial stiffness was defined as a pulse wave velocity ≥10 m/s.

RESULTS:

In men, only total cholesterol (OR=1.59; CI=1.02 to 2.48, p=0.04) was associated with the risk of increased arterial stiffness. In women, HDL-C (OR=1.99; CI=1.18 to 3.35, p=0.01) and non-HDL-C (OR=1.61; CI=1.01 to 2.56, p=0.04) were good predictors of the risk of increased arterial stiffness. However, these associations were only found in postmenopausal women (OR=2.06; CI=1.00 to 4.26, p=0.05 for HDL-C and OR=1.83; CI=1.01 to 3.33, p=0.04 for non-HDL-C).

CONCLUSION:

Our findings indicate that both HDL-C and non-HDL-C are good predictors of the risk of increased arterial stiffness in postmenopausal women in an urban Brazilian population and may be useful tools for assessing the risk of arterial stiffness.

Keywords: Non-HDL-C, Arterial Stiffness, Dyslipidemia, Menopause


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