Clinics (Sao Paulo). 2017 February; 72(2): 95-102.
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The Children–s Hospital of Zhejiang University School of Medicine, Department of Nephrology, Hangzhou 310003, Zhejiang Province, China
*Corresponding autor. E-mail:
received October 5, 2016; revised November 24, 2016; accepted November 24, 2016.
Henoch-Schönlein purpura nephritis and immunoglobulin A nephropathy are two diseases with similar clinical presentations but very different prognoses. Transforming growth factor β1 and monocyte chemoattractant protein-1 have been associated with the development of tissue fibrosis. We examined the development of tubulointerstitial fibrosis and its relationship with Transforming growth factor β1 and monocyte chemoattractant protein-1 expression in these patients.
Renal tissue samples were collected by renal biopsy from 50 children with Henoch-Schönlein purpura nephritis and 50 children with immunoglobulin A nephropathy. Hematoxylin and eosin and Masson's trichrome-stained tissues were examined using light microscopy. Tubulointerstitial fibrosis was graded using the method described by Bohle et al.
Transforming growth factor β1 and monocyte chemoattractant protein-1 expression in the renal tissues was significantly greater in the patients with immunoglobulin A nephropathy than in the patients with Henoch-Schönlein purpura nephritis (both
Transforming growth factor β1 and monocyte chemoattractant protein-1 expression was associated with the development of immunoglobulin A nephropathy and Henoch-Schönlein purpura nephritis. Further studies are needed to better evaluate this association.
Keywords: Henoch-Schönlein Purpura Nephritis, IgA Nephropathy, Immunohistochemistry, Monocyte Chemoattractant Protein-1, Transforming Growth Factor β1, Fibrosis
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