Clinics (Sao Paulo). 2017 March; 72(3): 161-170.

Copyright © 2017 CLINICS

Controlled clinical trial addressing teeth whitening with hydrogen peroxide in adolescents: a 12-month follow-up

Marcelo Mendes Pinto , Marcela Leticia Leal Gonçalves , Ana Carolina Costa da Mota , Alessandro Melo Deana , Silvia Regina Olivan , Carolina Bortoletto , Camila Haddad Leal de Godoy , Katia Lumi Tanikawa Vergilio , Olga Maria Altavista , Lara J Motta , Sandra Kalil Bussadori *

Universidade Nove de Julho, Programa de Pós-Graduação, Departamento de Biofotônica Aplicada às Ciências da Saúde, São Paulo/SP, Brazil

*Corresponding author. E-mail:

received September 16, 2016; revised November 18, 2016; accepted December 20, 2016.



To evaluate the colorimetric change in incisors and canines of adolescents aged 12 to 20 years submitted to at-home whitening and to evaluate satisfaction, sensitivity and discomfort during the procedures through a questionnaire.


Thirty adolescents were randomly assigned to the following groups: 1) 6.0% hydrogen peroxide (White Class with calcium – FGM); 2) 7.5% hydrogen peroxide (White Class with calcium - FGM); 3) 10% hydrogen peroxide (Oral B 3D White – Oral-B); 4) Control group – placebo. Assessments were performed prior to treatment as well as at 7, 30, 180 and 360 days after treatment. Friedman’s ANOVA was used to analyze color. The Kruskal-Wallis test followed by Dunn’s post hoc test was used to compare the groups at the different evaluation times. Answers on the questionnaires were ranked, and non-parametrical tests were employed. The groups were compared in each period using the Kruskal-Wallis test followed by the Student-Newman-Keuls test. Categorical data were analyzed using Fisher's exact test, and the Wilcoxon test was used for the analysis of different periods. P-values were corrected using the Hyan-Holm step-down Bonferroni procedure. NCT01998386.


Similar results were obtained one month after treatment with both tooth whitening gels and whitening strips. Patients were partially satisfied with the treatment after the first and second weeks and would recommend it. All products demonstrated color stability after 12 months of follow-up.


The bleaching procedure was efficient, and the patients could perceive its result. Further investigations are needed to determine the effects of bleaching on young teeth.

Keywords: Tooth Bleaching, Adolescent, Tooth Bleaching Agents

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