CLINICS

Clinics (Sao Paulo). 2017 August; 72(8): 499-509.
doi:10.6061/clinics/2017(08)08

Copyright © 2017 CLINICS

Systematic Review of Health Economic Evaluations of Diagnostic Tests in Brazil: How accurate are the results?

Maria Regina Fernandes Oliveira I IV , Roseli Leandro II III , Tassia Cristina Decimoni II , Luciana Martins Rozman II , Hillegonda Maria Dutilh Novaes II IV , Patrícia Coelho De Soárez II IV *

Faculdade de Medicina, Universidade de Brasilia, Campus Universitario Darcy Ribeiro, Brasilia, DF, BR

Departamento de Medicina Preventiva, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR

Hospital de Transplantes Euryclides de Jesus Zerbini, Sao Paulo, SP, BR

Instituto de Avaliacao de Tecnologias em Saude (IATS/CNPq), Porto Alegre, RS, BR

*Corresponding author. E-mail: patricia.soarez@usp.br

received November 3, 2016; revised January 26, 2017; accepted March 6, 2017.

Abstract

The aim of this study is to identify and characterize the health economic evaluations (HEEs) of diagnostic tests conducted in Brazil, in terms of their adherence to international guidelines for reporting economic studies and specific questions in test accuracy reports. We systematically searched multiple databases, selecting partial and full HEEs of diagnostic tests, published between 1980 and 2013. Two independent reviewers screened articles for relevance and extracted the data. We performed a qualitative narrative synthesis. Forty-three articles were reviewed. The most frequently studied diagnostic tests were laboratory tests (37.2%) and imaging tests (32.6%). Most were non-invasive tests (51.2%) and were performed in the adult population (48.8%). The intended purposes of the technologies evaluated were mostly diagnostic (69.8%), but diagnosis and treatment and screening, diagnosis, and treatment accounted for 25.6% and 4.7%, respectively. Of the reviewed studies, 12.5% described the methods used to estimate the quantities of resources, 33.3% reported the discount rate applied, and 29.2% listed the type of sensitivity analysis performed. Among the 12 cost-effectiveness analyses, only two studies (17%) referred to the application of formal methods to check the quality of the accuracy studies that provided support for the economic model. The existing Brazilian literature on the HEEs of diagnostic tests exhibited reasonably good performance. However, the following points still require improvement: 1) the methods used to estimate resource quantities and unit costs, 2) the discount rate, 3) descriptions of sensitivity analysis methods, 4) reporting of conflicts of interest, 5) evaluations of the quality of the accuracy studies considered in the cost-effectiveness models, and 6) the incorporation of accuracy measures into sensitivity analyses.

Keywords: Costs and Cost Analysis, Cost-Benefit Analysis, Health Care Costs, Diagnostic Tests Routine, Brazil


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