CLINICS

Clinics (Sao Paulo). 2017 October; 72(10): 595-599.
doi:10.6061/clinics/2017(10)02

Copyright © 2017 CLINICS

Longitudinal study of lung function in pregnant women: Influence of parity and smoking

Luciana Duzolina Manfré Pastro I * , Miriam Lemos II , Frederico Leon Arrabal Fernandes III , Silvia Regina Dias Médici Saldiva IV , Sandra Elisabete Vieira V , Beatriz Mangueira Saraiva Romanholo VI VII , Paulo Hilário Nascimento Saldiva II , Rossana Pulcineli Vieira Francisco I

Departamento de Ginecologia e Obstetricia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR

Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR

Laboratorio de Funcao Pulmonar, Disciplina de Pulmonologia, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR

Instituto de Saude, Secretaria de Estado da Saude, Sao Paulo, SP, BR

Departamento de Pediatria, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR

Departamento de Medicina (LIM 20), Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR

Universidade Cidade de Sao Paulo (UNICID), Sao Paulo, SP, BR

*Corresponding author. E-mail: lucianapastro@usp.br

received February 17, 2017; revised April 11, 2017; accepted May 10, 2017.

Abstract

OBJECTIVES:

To evaluate pulmonary function in the first and third trimesters of pregnancy and analyze the influence of parity and smoking on spirometry parameters.

METHODS:

This longitudinal prospective study included a cohort of 120 pregnant women. The inclusion criteria were as follows: singleton pregnancy, gestational age less than 13.86 weeks, and no preexisting maternal diseases. The exclusion criteria were as follows: change of address, abortion, and inadequate spirometry testing. ClinicalTrials.gov: NCT02807038.

RESULTS:

A decrease in values of forced vital capacity and forced expiratory volume were noted in the first second from the first to third trimester. In the first and third trimesters, multiparous women demonstrated lower absolute forced vital capacity and forced expiratory volume values in the first second compared with nulliparous women (p<0.0001 and p=0.001, respectively). Multiparous women demonstrated reduced forced expiratory flow in 25% to 75% of the maneuver compared with nulliparous women in the first (p=0.005) and third (p=0.031) trimesters. The absolute values of forced expiratory flow in 25% to 75%, forced expiratory volume in the first second and predicted peak expiratory flow values in the third trimester were higher in smokers compared with nonsmokers (p=0.042, p=0.039, p=0.024, and p=0.021, respectively).

CONCLUSION:

There was a significant reduction in forced vital capacity and forced expiratory volume values in the first second during pregnancy. Parity and smoking significantly influence spirometric variables.

Keywords: Spirometry, Pregnancy, Pulmonary Function Test, Parity, Smoking


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