Clinics (Sao Paulo). 2017 October; 72(10): 642-644.
doi:10.6061/clinics/2017(10)09
Copyright © 2017 CLINICS
Plasmid-mediated mcr-1 in carbapenem-susceptible Escherichia coli ST156 causing a blood infection: an unnoticeable spread of colistin resistance in Brazil?
Divisao Laboratorio Central – LIM03, Setor de Microbiologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR
Departamento de Bioquímica, Instituto de Química, Universidade de Sao Paulo, Sao Paulo, SP, BR
Nucleo de Apoio a Pesquisa em Biologia Computacional e Genomica (NUBIC), Universidade de Sao Paulo, Sao Paulo, SP, BR
Instituto do Cancer do Estado de Sao Paulo, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR
*Corresponding author. E-mail:
received March 7, 2017; revised May 23, 2017; accepted May 30, 2017.
Abstract
OBJECTIVE:
We describe an IncX4 pHC891/16mcr plasmid carrying
METHODS:
Strain HC891/16 was subjected to whole genome sequencing using the MiSeq Platform (Illumina, Inc., USA). Assembly was performed using Mira and ABACAS.
RESULTS:
The isolates showed resistance only to ciprofloxacin, ampicillin and cefoxitin, and whole-genome sequencing revealed the presence of
CONCLUSION:
Our findings warn of the possible silent dissemination of colistin resistance by carbapenem-susceptible
Keywords: Colistin Resistance, Polymyxin Resistance, Escherichia Coli, Carbapenem-Susceptible, ST156
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