Clinics (Sao Paulo). 2011 May; 66(5): 743-746.

Copyright © 2011 Hospital das Clínicas da FMUSP

The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration

Zuhal Yildirim I , Nil Irem Ucgun II , Filiz Yildirim III

Etimesgut Public Health Laboratory, Ankara, Turkey.

Second Ophthalmology Clinic, Ankara Numune Education and Research Hospital, Ankara, Turkey.

Duatepe Government Hospital, Clinic of Internal Medicine, PolatlI, Ankara, Turkey.

E-mail: Tel.: 90 544 411 1594

received December 28, 2010; revised February 2, 2011; accepted February 2, 2011.



To investigate the role of oxidant/antioxidant status and protein oxidation in the development of age-related macular degeneration.


The activities of serum superoxide dismutase and glutathione peroxidase and the levels of serum malondialdehyde, advanced oxidation protein products, glutathione and vitamin C were measured in 25 patients with age-related macular degeneration and 25 control subjects without age-related macular degeneration.


The malondialdehyde and advanced oxidation protein product levels in the serum were significantly higher in the age-related macular degeneration patient group than in the control group (p<0.05). The superoxide dismutase activity in the serum was significantly lower in the age-related macular degeneration patient group than in the control group (p<0.05). The levels of vitamin C and glutathione and the activity of glutathione peroxidase in the serum were unchanged between groups (p>0.05).


The results of the present study suggest that decreased effectiveness of the antioxidant defense system and increased oxidative stress may play a role in the pathogenesis of age-related macular degeneration.

Keywords: Oxidative stress, Antioxidants, Protein oxidation, AMD

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