CLINICS

Clinics (Sao Paulo). 2011 May; 66(5): 811-815.
doi:10.1590/S1807-59322011000500017

Copyright © 2011 Hospital das Clínicas da FMUSP

A comparison of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion for oocyte retrieval

Demet Coskun , Berrin Gunaydin , Ayca Tas , Gozde Inan , Hulya Celebi , Kadir Kaya

Department of Anaesthesiology and Reanimation, Gazi University Faculty of Medicine, Ankara, Turkey.

E-mail: dcoskun@gazi.edu.tr Tel.: 90 312 202 53 10

received February 11, 2011; revised February 14, 2011; accepted February 14, 2011.

Abstract

OBJECTIVE:

To evaluate the effects of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion on hemodynamic parameters, pain, sedation, and recovery score during oocyte retrieval.

METHODS:

Sixty-nine women were scheduled for oocyte retrieval. Target-controlled propofol infusion at an effect-site concentration of 1.5 µg/mL was instituted. The patients were randomly allocated to receive remifentanil at an effect-site concentration of either 1.5 (group I, n = 23), 2 (group II, n = 23) or 2.5 ng/mL (group III, n = 23). Hemodynamic variables, sedation, pain, the Aldrete recovery score, and side effects were recorded.

RESULTS:

Hemodynamic variables, sedation and pain scores and the number of patients with the maximum Aldrete recovery score 10 min after the procedure were comparable among the groups. The number of patients in group III with the maximum Aldrete recovery score 5 min after the procedure was significantly lower than that in groups I and II. One patient in group II and one patient in group III suffered from nausea.

CONCLUSION:

Similar pain-free conscious sedation conditions without significant changes in hemodynamic parameters were provided by all three protocols. However, target controlled infusion of remifentanil at 1.5 or 2 ng/mL proved superior at providing early recovery compared to 2.5 ng/mL.

Keywords: Target-Controlled Infusion, Propofol, Remifentanil, Oocyte Retrieval, Sedation


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