Clinics (Sao Paulo). 2017 October; 72(10): 637-641.

Copyright © 2017 CLINICS

Review of magnetic resonance-guided focused ultrasound in the treatment of uterine fibroids

Pedro Felipe Magalhães Peregrino , Marcos de Lorenzo Messina , Ricardo dos Santos Simões , José Maria Soares-Júnior * , Edmund Chada Baracat

Disciplina de Ginecologia, Departamento de Obstetricia e Ginecologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR

*Corresponding author. E-mail:

received December 15, 2016; revised February 16, 2017; accepted April 4, 2017.


Uterine leiomyoma is the most frequently occurring solid pelvic tumor in women during the reproductive period. Magnetic resonance-guided high-intensity focused ultrasound is a promising technique for decreasing menorrhagia and dysmenorrhea in symptomatic women. The aim of this study is to review the role of Magnetic resonance-guided high-intensity focused ultrasound in the treatment of uterine fibroids in symptomatic patients. We performed a review of the MEDLINE and Cochrane databases up to April 2016. The analysis and data collection were performed using the following keywords: Leiomyoma, High-Intensity Focused Ultrasound Ablation, Ultrasonography, Magnetic Resonance Imaging, Menorrhagia. Two reviewers independently performed a quality assessment; when there was a disagreement, a third reviewer was consulted. Nineteen studies of Magnetic resonance-guided high-intensity focused ultrasound-treated fibroid patients were selected. The data indicated that tumor size was reduced and that symptoms were improved after treatment. There were few adverse effects, and they were not severe. Some studies have reported that in some cases, additional sessions of Magnetic resonance-guided high-intensity focused ultrasound or other interventions, such as myomectomy, uterine artery embolization or even hysterectomy, were necessary. This review suggests that Magnetic resonance-guided high-intensity focused ultrasound is a safe and effective technique. However, additional evidence from future studies will be required before the technique can be recommended as an alternative treatment for fibroids.


A uterine fibroid is a benign neoplasia originating from smooth muscle tissue. Uterine fibroids are classified as subserosal, intramural, and submucosal based on their location within the uterus. These different types of uterine fibroids may have diverse manifestations. The main symptoms are intense or prolonged menstrual bleeding (menorrhagia), dysmenorrhea, dyspareunia, adjacent organ compression (bladder and bowel), urinary incontinence, increased abdominal volume, infertility, and repeated miscarriages 1-3. Menorrhagia may cause anemia, which together with dysmenorrhea and dyspareunia, has a negative effect on the quality of life of these women. The increase in abdominal volume and the compression of adjacent organs may affect the intestinal and urinary habits of the patient, in addition to causing discomfort 3.

The classic treatments for fibroids include excision of the tumors and hysterectomy. However, such techniques may be very costly due to the length of surgery, increased bleeding risk, longer hospitalization, and possible postoperative complications. Therefore, researchers are developing new techniques such as magnetic resonance-guided high-intensity focused ultrasound (MRgFUS) 4-6.

MRgFUS is a minimally invasive therapy capable of producing necrosis by thermal coagulation of myometrial nodules at a precise location in the uterus 4. It is primarily used to decrease the volume of fibroids and to reduce complaints about symptoms. However, in many centers, MRgFUS is currently neither advocated nor established as an alternative therapy. Initial studies comprising various cohort sizes reported significant symptom improvement in response to MRgFUS. Even with partial results, MRgFUS has been shown to be an efficient and minimally invasive method for treating uterine fibroids 4-6.

Most of the studies in which MRgFUS has been used are case studies. Therefore, it is necessary to perform a systematic review of the studies to better assess MRgFUS as a therapeutic modality for uterine fibroids in symptomatic women during the reproductive period.


A review was conducted using articles in English, Spanish and Portuguese without publication year restriction up to April 2016 and retrieved from the MEDLINE and Cochrane databases. The following inclusion criteria were used: a) studies including patients of reproductive age with uterine fibroids; b) studies including patients with menorrhagic cycles, dysmenorrhea, and an increase in abdominal volume; c) the use of MRgFUS for the treatment of uterine fibroids. The exclusion criteria were as follows: a) studies of animal models; b) studies that included asymptomatic women; c) narrative reviews; d) case reports; e) cost assessments of therapeutic methods; f) comparisons of different techniques of the MRgFUS method; g) evaluation or study of the MRgFUS technique; h) studies with different protocols for the use of MRgFUS; i) studies that used a non-validated questionnaire.

Articles were retrieved using the search strategies described in Box 1 and were grouped and structured according to the PICO strategy (the initials for “Patient”, “Intervention,” “Control” and “Outcome”). The search strategy is described in Figure 1.

Databases and search strategies.

Medline: (Myoma OR Leiomyoma OR Fibroid OR Fibroids) AND (High-Intensity Focused Ultrasound Ablation OR High-Intensity Focused Ultrasound Ablation OR Ultrasonic Therapy OR HIFU OR MR-guided focused ultrasound OR MRgFUS). (N=207)

Cϕchrane: Leiomyoma AND High-Intensity Focused Ultrasound Ablation (N=8)

The references cited in the articles retrieved from the database were also evaluated. Systematic reviews and meta-analyses were consulted, but only the original articles were used. Two reviewers independently assessed the quality of the studies; when there was a disagreement, a third reviewer was consulted. The JADAD scale was used for the critical analysis of Randomized clinical trial.


During the investigated period, a total of 207 articles were found in MEDLINE and 8 articles were found the in the Cochrane database (Figure 1). After the titles and abstracts were read and the eligibility criteria were applied, 188 articles were excluded (incomplete reviews, case reports, studies of therapy costs, studies in animal models, and studies of the comparisons of the different techniques of the MRgFUS method or studies with different protocols for the use of MRgFUS). The remaining 19 papers were included in this review 7-25.

The effects of MRgFUS on fibroid volume and on the patients’ symptoms and quality of life are summarized in Tables 1 and 2. In the 19 selected studies, patient age ranged from 32 to 50 years, and follow-up lasted from 3 to 36 months. This review comprised case studies and one clinical trial 24. Fibroid volume decreased in all the included studies; however, there was a discrepancy in the percentage reduction after MRgFUS. The decrease in fibroid volume ranged from 9,3% to 90% 11,19, as shown in Table 1.

Most studies used assessment questionnaires that have been validated in the literature. These assessments indicated that MRgFUS might improve the patients’ symptoms and quality of life 7-14,17-19,23-24. Some articles used only the symptom severity score (SSS), which is part of the Uterine Fibroid Symptom and Health-Related Quality of Life Questionnaire (UFS-QOL) to assess symptom improvement in patients. In the UFS-QOL, the SSS mainly analyzes symptoms such as menorrhagia and bulk-related symptoms. Three studies did not use validated questionnaires to evaluate quality of life or symptom improvement 14,20,25 or did not administer any specific questionnaires to evaluate patients’ symptoms and quality of life. These studies were included only in the analysis of the fibroid volume reduction. The decrease in the SSS ranged from 32% to 74%. Four studies used the complete UFS-QOL and reported increases in quality of life ranging from 20% to 47%. The only clinical trial included in this review analyzed 109 women with fibroids and showed a significant reduction of severe symptoms (51%) at 12 months of follow-up, which was statistically significant (p<0.001).

No severe complications were observed in the studies included in the analysis. The main complaints after MRgFUS were abdominal pain and lumbar pain, which improved with a mild analgesic. Two studies reported abdominal pain due to the accumulation of contrast material in the muscular and subcutaneous layers of the abdominal wall in 9% and 11% of the patients, respectively 7,13. In some cases, the necrotic material was expelled via the vagina after treatment over the subsequent menstrual cycles 11. The most severe complications occurred in a patient who developed deep vein thrombosis and required longer hospitalization 14 and in 2 patients who had endometritis with subsequent hysterectomy 15.

In some studies, new interventions were required because the patients’ symptoms persisted or worsened 8,12,15,17,21. For these reasons, Mindjuk et al. 8 reported a 12.7% rate of additional treatments such as hysterectomy, myomectomy, or embolization of uterine blood vessels. In the Funaki et al. 17 study, 1 patient underwent a hysterectomy, 5 patients underwent a myomectomy, and 5 others underwent a repeat MRgFUS after the primary treatment.


The American College of Obstetricians and Gynecologists (ACOG) recommends that hysterectomies be included as an option for the treatment of benign conditions such as leiomyoma 26. Otherwise, myomectomy is the treatment of choice 1-3. However, recovery time, prolonged hospitalization, high rates of complications that may occur intraoperatively, and possible hysterectomies can be avoided. In this systematic review, MRgFUS was evaluated and found to be effective, promising, and safe for the treatment of benign uterine tumors. Hence, minimally invasive techniques such as MRgFUS may be an option, but further studies with a longer follow-up are necessary.

Since the introduction of MRgFUS and its approval by the FDA as a therapeutic modality (2004), several studies have been conducted and have reported symptom improvement in leiomyoma patients 6, as discussed in this review. The articles included in this study were mostly case series because it is difficult to conduct double-blind controlled studies with MRgFUS. This fact limits the design and performance of these studies. Additionally, the technique used with MRgFUS is very different from minimally invasive techniques such as embolization of uterine arteries 27.

Patient follow-up after MRgFUS lasted at least 3 months 7,10,13 and at most 36 months 14. Regardless of the variability in the length of follow-up, the studies under investigation reported reduced fibroid volume and a reduction in the patients’ symptoms. To assess the volume reduction, the nonperfused volume (NPV) after MRgFUS was considered. Only 9 of the 19 studies included in this review had an NPV over 50%. Although higher NPVs are associated with greater efficacy, symptom improvement was similar among the studies. It is possible that unevaluated uterine factors occurred after MRgFUS. Potential endometrial alterations may have a considerable impact on the uterus, primarily on a woman’s reproductive future. The studies included in this review did not evaluate this potential impact, i.e., they did not attempt to determine the feasibility of using the MRgFUS method in women with a desire to have children.

The differences in the previously mentioned results may be explained by the variety of fibroid types and the variation in signal intensity in the MRI T2 images soon after treatment 20,24. Tumors generating an MRI T2 hyposignal tend to exhibit higher necrosis rates and, consequently, larger reductions in fibroid volume. The reason for this is still unknown, but it seems to depend on both tumor volume and factors such as fibroid vascularization, intramural components, lesion density, and tumor-specific hormone expression 23.

Quality of life and obvious symptoms were assessed using the UFS-QOL. One potential limitation of the present study is that three of the included articles did not address variables of intense symptoms 15,21,25. A low SSS (a component of the UFS-QOL) indicates an improvement in symptoms, whereas an overall low UFS-QOL score indicates an enhancement of the patient’s quality of life. The articles in this review showed that the use of MRgFUS favors improvements in severe symptoms, as well as in the overall quality of life, despite the wide range of the follow-up time and the age of the study patients.

The SSS questionnaire primarily evaluates symptoms such as menorrhagia; therefore, its scores are more meaningful in studies of patients with intramural or submucosal fibroids. Taking this into consideration, Park et al. 10 studied 9 women with subserosal fibroids whose main complaints were mass effect and increased abdominal volume. They concluded that there was a significant reduction in volume and in mass effect (89%) but only a slight improvement in the SSS.

A better quality of life and improvements in bleeding and dysmenorrhea are also related to a larger NPV 11-13,19,23. Stewart et al. 23, whose study included more patients than any of the other studies in this review, analyzed 359 patients from all the clinical trials of MRgFUS in the treatment of fibroids and found that symptom improvement was significant. Furthermore, after a 24-month follow-up, they concluded that the SSS improvement was, on average, 6 points larger in the group of patients with the greater NPV. The relationship between NPV and symptom improvement may also be explained by the association of an MRI T2 hyposignal and a larger NPV, as found in some of the previously mentioned studies.

In all the studies included in the present analysis, the rates of adverse effects and complications following MRgFUS were low. The most common symptoms were abdominal pain, lumbar pain, first-degree burns, and light vaginal bleeding. The abdominal pain and lumbar pain were relieved with a common, mild analgesic. There was also pain caused by the accumulation of contrast material in the muscle and subcutaneous layers of the abdominal wall 7,13. However, neither hospitalization nor intervention were subsequently required to treat such complications. In general, tumors are highly vascularized and may undergo a parturition process after necrosis. In a few cases, the necrotic material was expelled via the vagina after treatment and disappeared after 4 menstrual cycles 11. The most severe complications were a case of deep vein thrombosis in 1 patient, which entailed a longer hospital stay 15, and 2 cases of endometritis requiring subsequent hysterectomy 16. Cases requiring intervention immediately after MRgFUS were rare. Hysterectomy, myomectomy, or uterine artery embolization was required for patients whose condition worsened or whose dysmenorrhea or hypermenorrhea relapsed.

To date, there are no randomized clinical trials that are suitable for inclusion in a meta-analysis, which would provide a more robust analysis. Our review suggests that MRgFUS is an effective and promising therapeutic technique for decreasing myoma volume and patients’ symptoms. However, further controlled and randomized studies will be required before MRgFUS can be recommended as an alternative fibroid treatment 7-25.


Peregrino PF designed the study and was responsible for the analysis of data and manuscript writing. Messina ML designed the study, wrote and revised the manuscript. Simões RS designed the study and was responsible for the analysis of data and manuscript writing. Soares-Júnior JM designed the study and was responsible for the analysis of data and manuscript writing. Baracat EC designed the study and wrote and revised the manuscript.


No potential conflict of interest was reported.


1 Vollenhoven BJ, Lawrence AS, Healy DL. Uterine fibroids: a clinical review. Br J Obstet Gynaecol. 1990;97:(4). 285-98.

2 Borsari R, Bozzini N, Junqueira CR, Soares Jr, Hilário SG, Baracat EC. Genic expression of the uterine leiomyoma in reproductive-aged women after treatment with goserelin. Fertil Steril. 2010;94:(3). 1072-7.

3 Bittencourt CA, Dos Santos Simões R, Bernardo WM, Fuchs LF, Soares Júnior JM, Pastore AR, et al. Accuracy of saline contrast sonohysterography in detection of endometrial polyps and submucosal leiomyomas in women of reproductive age with abnormal uterine bleeding: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2017;50:(1). 32-9.

4 Cline HE, Hynynen K, Watkins RD, Adams WJ, Schenck JF, Ettinger RH, et al. Focused US system for MR imaging-guided tumor ablation. Radiology. 1995;194:(3). 731-7.

5 Fennessy FM, Tempany CM, McDannold NJ, So MJ, Hesley G, Gostout B, et al. Uterine leiomyomas: MR imaging-guided focused ultrasound surgery—results of different treatment protocols. Radiology. 2007;243:(3). 885-93.

6 Hesley GK, Felmlee JP, Gebhart JB, Dunagan KT, Gorny KR, Kesler JB, et al. Noninvasive treatment of uterine fibroids: early Mayo Clinic experience with magnetic resonance imaging-guided focused ultrasound. Mayo Clin Proc. 2006;81:(7). 936-42.

7 Park MJ, Kim YS, Rhim H, Lim HK. Safety and therapeutic efficacy of complete or near-complete ablation of symptomatic uterine fibroid tumors by MR imaging-guided high-intensity focused US therapy. J Vasc Interv Radiol. 2014;25:(2). 231-9.

8 Mindjuk I, Trumm CG, Herzog P, Stahl R, Matzko M. MRI predictors of clinical success in MR-guided focused ultrasound (MRgFUS) treatments of uterine fibroids: results from a single centre. Eur Radiol. 2015;25:(5). 1317-28.

9 Ikink ME, Voogt MJ, Verkooijen HM, Lohle PN, Schweitzer KJ, Franx A, et al. Mid-term clinical efficacy of a volumetric magnetic resonance-guided high-intensity focused ultrasound technique for treatment of symptomatic uterine fibroids. Eur Radiol. 2013;23:(11). 3054-61.

10 Park H, Yoon SW, Kim KA, Jung Kim D, Jung SG. Magnetic resonance imaging-guided focused ultrasound treatment of pedunculated subserosal uterine fibroids: a preliminary report. J Vasc Interv Radiol. 2012;23:(12). 1589-93.

11 Wang W, Wang Y, Wang T, Wang J, Wang L, Tang J. Safety and efficacy of US-guided high-intensity focused ultrasound for treatment of submucosal fibroids. Eur Radiol. 2012;22:(11). 2553-8.

12 Dobrotwir A, Pun E. Clinical 24 month experience of the first MRgFUS unit for treatment of uterine fibroids in Australia. J Med Imaging Radiat Oncol. 2012;56:(4). 409-16.

13 Kim YS, Kim JH, Rhim H, Lim HK, Keserci B, Bae DS, et al. Volumetric MR-guided high-intensity focused ultrasound ablation with a one-layer strategy to treat large uterine fibroids: initial clinical outcomes. Radiology. 2012;263:(2). 600-9.

14 Kim HS, Baik JH, Pham LD, Jacobs MA. MR-guided high-intensity focused ultrasound treatment for symptomatic uterine leiomyomata: long-term outcomes. Acad Radiol. 2011;18:(8). 970-6.

15 Gorny KR, Woodrum DA, Brown DL, Henrichsen TL, Weaver AL, Amrami KK, Hangiandreou NJ, et al. Magnetic resonance-guided focused ultrasound of uterine leiomyomas: review of a 12-month outcome of 130 clinical patients. J Vasc Interv Radiol. 2011;22:(6). 857-64.

16 LeBlang SD, Hoctor K, Steinberg FL. Leiomyoma shrinkage after MRI-guided focused ultrasound treatment: report of 80 patients. AJR Am J Roentgenol. 2010;194:(1). 274-80.

17 Funaki K, Fukunishi H, Sawada K. Clinical outcomes of magnetic resonance-guided focused ultrasound surgery for uterine myomas: 24-month follow-up. Ultrasound Obstet Gynecol. 2009;34:(5). 584-9.

18 Harding G, Coyne KS, Thompson CL, Spies JB. The responsiveness of the uterine fibroid symptom and health-related quality of life questionnaire (UFS-QOL). Health Qual Life Outcomes. 2008;6:99-

19 Lénárd ZM, McDannold NJ, Fennessy FM, Stewart EA, Jolesz FA, Hynynen K, et al. Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--imaging predictors of success. Radiology. 2008;249:(1). 187-94.

20 Morita Y, Ito N, Hikida H, Takeuchi S, Nakamura K, Ohashi H. Non-invasive magnetic resonance imaging-guided focused ultrasound treatment for uterine fibroids - early experience. Eur J Obstet Gynecol Reprod Biol. 2008;139:(2). 199-203.

21 Mikami K, Murakami T, Okada A, Osuga K, Tomoda K, Nakamura H. Magnetic resonance imaging-guided focused ultrasound ablation of uterine fibroids: early clinical experience. Radiat Med. 2008;26:(4). 198-205.

22 Rabinovici J, Inbar Y, Revel A, Zalel Y, Gomori JM, Itzchak Y, et al. Clinical improvement and shrinkage of uterine fibroids after thermal ablation by magnetic resonance-guided focused ultrasound surgery. Ultrasound Obstet Gynecol. 2007;30:(5). 771-7.

23 Stewart EA, Gostout B, Rabinovici J, Kim HS, Regan L, Tempany CM. Sustained relief of leiomyoma symptoms by using focused ultrasound surgery. Obstet Gynecol. 2007;110:(2 Pt 1). 279-87.

24 Stewart EA, Rabinovici J, Tempany CM, Inbar Y, Regan L, Gostout B, et al. Clinical outcomes of focused ultrasound surgery for the treatment of uterine fibroids. Fertil Steril. 2006;85:(1). 22-9.

25 Hindley J, Gedroyc WM, Regan L, Stewart E, Tempany C, Hynyen K, et al. MRI guidance of focused ultrasound therapy of uterine fibroids: early results. AJR Am J Roentgenol. 2004;183:(6). 1713-9.

26 Broder MS, Kanouse DE, Mittman BS, Bernstein SJ. The appropriateness of recommendations for hysterectomy. Obstet Gynecol. 2000;95:(2). 199-205.

27 Froeling V, Meckelburg K, Schreiter NF, Scheurig-Muenkler C, Kamp J, Maurer MH, et al. Outcome of uterine artery embolization versus MR-guided high-intensity focused ultrasound treatment for uterine fibroids: long-term results. Eur J Radiol. 2013;82:(12). 2265-9.

Keywords: Leiomyoma, High-Intensity Focused Ultrasound Ablation, Ultrasonography, Magnetic Resonance Imaging, Menorrhagia

Articles from Clinics are provided here courtesy of
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

2nd © Copyright 2007 - Revista Clinics - All rights reserved